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Transmissible Spongiform Encephalopathies (TSEs) are a group of rare progressive neurodegenerative diseases that occur in both humans and animals. The cause of TSEs is believed to be prions, or pathogenic agents that are transmissible and which induce abnormal folding of specific normal cellular proteins (called prion proteins) found in the brain. The abnormal folding induced by the prions leads to brain damage and characteristic symptoms of the disease.
Human TSEs (Prion Diseases)
Creutzfeldt-Jakob Disease (CJD) is the prototypical human TSE. It is rare, occurring at a rate of one per million worldwide. Primary symptoms of CJD are dementia, followed by rapid mental deterioration. Other symptoms include myoclonus (irregular, involuntary contraction of a muscle), rigidity, nystagmus (rapid, involuntary oscillation of the eyeballs), tremors and visual deficits.
CJD is not contagious person to person, although cases have arisen from various types of tissue transplants and from human growth hormone injections. Hospital guidelines have been developed to avoid those types of transmission.
A new variant of CJD was detected in 1995, now referred to as vCJD.
Variant Creutzfeld-Jakob Disease (vCJD): There are strong indications that the same agent responsible for BSE ("mad cow disease") outbreaks in cattle is also responsible for vCJD incidences in humans. Both disorders are fatal brain diseases with unusually long incubation periods and are caused by an unconventional transmissible agent. Humans may develop vCJD after eating infected products from cattle with mad cow disease.
Symptoms may include pain or paresthesias (a sensation of prickling, tingling or creeping on the skin), psychosis, depression and anxiety.
Clinical differences between vCJD and CJD include the following: In vCJD, psychological disorders and sensory deficits are typically more pronounced when the disease is first detected than they are with CJD. 99% of CJD victims are 35 or older, while vCJD victims are younger, with a median age of 27.5. Patients with vCJD have a relatively longer duration of illness (median of 14 months as opposed to 4.5 months); additionally, vCJD is strongly linked to exposure, probably through food, to BSE.
Finally, vCJD patients tend to develop amyloid plaques in the brain, while CJD patients do not.
Since the incubation period for vCJD is unknown, possible cases of vCJD in the next few years range from hundreds to tens of thousands.
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Animal TSEs (Prion Diseases)
Chronic wasting disease (CWD) primarily affects deer, but has also been diagnosed in elk. The animals become listless, emaciated, polyuric (have an excessive secretion of urine), polydipsic (are excessively thirsty), and they also drool excessively.
Deer affected by the disease were originally thought to be suffering from a nutritional deficiency, but in 1978 lesions were discovered in the brain like those seen in TSE. So far CWD has been identified in free roaming deer and elk in Wyoming and Colorado, as well as in captive, farmed herds of elk in Nebraska, South Dakota and Oklahoma. Surveillance systems have been established to monitor CWD in captive and hunted deer and elk.
Bovine spongiform encephalopathy (BSE, more commonly known as "mad cow disease") was first identified in 1986 by British veterinarians. Affected animals exhibit nervousness, heightened senses, weight loss and diminished milk production. As the disease progresses, the animals have difficulty walking and holding up their heads. By 1992 nearly 1,000 per week cases were reported in Britain.
Since then, the United States has maintained a BSE surveillance system on both the state and federal levels. There is a strict enforcement of import restrictions on ruminants (animals which are characterized by chewing again that which has already been swallowed) and ruminant products from any country where BSE exists, and a domestic FDA ban on animal-derived feeds.
Heart disease is the state's leading cause of death, and Mississippi's rates of heart disease are among the nation's highest. Cancer is the second leading cause of death.
For death and marriage certificate applications whose fees have been paid, the certified copy will be mailed to the customer within 7-10 business days. Can I order a birth certificate by phone? To order by phone, please call 1-877-295-4229.
What We Do. Public health protection takes a wide variety of forms, from ensuring the safety of your food and water to setting standards for health and care facilities.
About Vital Records from Mississippi Vital Records
Certified copies may be ordered in person, by mail or if paying by credit card, online or by telephone. Processing time is 7-10 business days after receipt of request for Regular Mail and 3-5 business days after receipt of request for UPS Express Service .
Mississippi ranked 51st among 50 states and Washington, D.C., with an average life expectancy at birth of 71.9 years in 2020. This was a decline from 2019, when the state's average life expectancy at birth was 74.4 years. Hawaii ranked first with an average life expectancy. of 80.7 years.
There is no fee to use FamilySearch, but you must create a free, personal account to access the databases and digital records. Information about how to access birth, death, and marriage records and indexes maintained by the Mississippi Department of Archives and History..
The fee for a certified copy of a death certificate is $17. Each additional copy ordered at the same time costs $6. If the date of death is uncertain, a five-year search of our records will be made. If the record is not on file, only the fees paid for any additional copies, if any, will be refunded.
Autopsy reports are usually completed within 60 days from the date of autopsy; however, there are cases which can take 90 days or longer depending on the complexity of the case.
A nurse shortage accelerated during the COVID-19 pandemic and the exodus has added further strain on the health care system in Mississippi. A spokesperson for the health department, Liz Sharlot, said 54% of rural hospitals are in danger of closure or downgrading existing services.
You can order birth certificates, death certificates and marriage records on-line, by mail, phone or in person by visiting our Vital Records office. Birth certificates cost $17, with a $6 fee for additional copies of the same record.
Why does it take so long to receive a copy of my record? Due to the high volume of incoming applications, it may take some time to receive a copy of a certificate.
While Mississippi managed to lower its opioid death rate by 10% in 2022, it still leads the nation in firearm deaths. And while the state's obesity and diabetes rates have declined recently, they remain among the nation's highest, with heart disease still the state's leading cause of death, the report says.
Heart disease is the leading cause of death for both men and women. This is the case in the U.S. and worldwide. More than half of all people who die due to heart disease are men. Medical professionals use the term heart disease to describe several conditions.
Mississippi is one of the top states in the nation for heart attack and stroke deaths. Obesity, smoking, diet and inactivity bring heart disease to Mississippians early in life, and cuts their lives short. 8,000 Mississippians a year die from heart disease.
Introduction: My name is Dan Stracke, I am a homely, gleaming, glamorous, inquisitive, homely, gorgeous, light person who loves writing and wants to share my knowledge and understanding with you.
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